學術資源整合系統-相關推薦
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| 作者 | Gu Shi-Hong |
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| 出版日期 | 202607 |
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| 著作名稱 | Temporal Dynamics of Extracellular Signal-Regulated Kinase Phosphorylation and Associated Signaling Genes During Embryonic Development in Bombyx mori
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| 刊名 | Archives of Insect Biochemistry and Physiology |
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| 卷 | 122 |
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| 期 | 3 |
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| 頁數 | e70194 |
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| 被收錄索引 | SCI;SCI |
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| 主題 | 動物;動物 |
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| 關鍵字 | FGF; Jeb/Alk; MAPK; RTK; TGF‐β; embryonic diapause; huckebein; pointed. |
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| 摘要 | This study investigated the temporal dynamics of extracellular signal-regulated kinase (ERK) phosphorylation, together with the expression profiles of its putative upstream ligands and downstream target genes, during embryonic development in Bombyx mori. The results revealed distinct ERK phosphorylation dynamics: significantly higher levels of phosphorylated ERK were observed between Days 1 and 6 after oviposition in developing eggs (non-diapause and HCl-treated eggs), whereas diapause eggs exhibited low levels. The temporal expression patterns of genes in the prothoracicotropic hormone (PTTH)/torso and epidermal growth factor (EGF) signaling pathways-spitz (spi), rhomboid (rho), and Egf receptor (Egfr)-did not differ between diapause and HCl-treated eggs. In contrast, the EGF pathway gene vein (vn) and genes in the transforming growth factor (TGF)-β signaling pathway-including the ligand myoglianin (myo) and its receptor babo-displayed distinct temporal expression patterns. Similarly, Jelly belly (Jeb)/anaplastic lymphoma kinase (Alk), fibroblast growth factor (Fgf)/Fgf receptor (Fgfr), neurotrophin (NT), and Toll-receptor ligands (spätzle family members (spz2, spz4, and spz5)) showed differential expression, with levels significantly elevated during the middle and late stages of embryonic development in HCl-treated eggs. Non-diapause and chilled eggs also exhibited increasing expression patterns of these genes, similar to those observed in HCl-treated eggs. Additionally, ERK target genes pointed and huckebein (hkb) showed higher and broader expression peaks in developing eggs compared to diapause eggs. This study provides a comprehensive analysis of the transcriptional regulation of upstream and downstream ERK signaling components during embryonic development and reveals new insights into the mechanisms underlying embryonic diapause. |
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| 資料連結 | ![Full Text]() |
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| 計畫主持人 | 顧世紅 |
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| 計畫編號 | NSTC 114-2313-B-178-001 |
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| 計畫年度 | 2024 |
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| 計畫委託單位 | 國家科學及技術委員會 |
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| 計畫名稱 | 昆蟲胰島素的新功能：前胸腺自體分泌因子的探索(二) |
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| 系統號 | NO000007728 |
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