學術資源整合系統-相關推薦
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| 作者 | Suzuki T;Gu SH |
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| 出版日期 | 2025 |
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| 已接受 | 202509 |
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| 著作名稱 | Systemic positive feedback regulation of ecdysone biosynthesis via sugar metabolism in insects
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| 刊名 | Developmental Biology |
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| 卷 | 525 |
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| 頁數 | 122-129 |
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| 被收錄索引 | SCI;SCI |
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| 主題 | 動物 |
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| 關鍵字 | PTTH; signaling; development; ecdysone; feedback; sugar transporters |
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| 摘要 | Insects are recognized as the most diverse species in the world. They are classified into three separate groups based on their developmental characteristics: ametabola, hemimetabola, and holometabola. Holometabolous insects have attracted the attention of many developmental biologists because of their dramatic metamorphosis as a key model for studying regulatory mechanisms of development. Central to this process is ecdysone, a steroid hormone that governs insect growth and maturation. Extensive research has clarified ecdysone’s structure, functions, and signaling pathways. In particular, the regulatory mechanisms of ecdysone synthesis have been a core research topic. Classical experiments, including ligation and tissue transplantation, established that the prothoracic glands are the primary site of ecdysone production and are activated by brain-derived prothoracicotropic hormone (PTTH). PTTH was first purified from silkworm brains, where it was shown to stimulate ecdysone secretion from the prothoracic glands directly. Although PTTH was identified decades ago, the molecular mechanisms linking PTTH signaling to enhanced ecdysone biosynthesis remain poorly understood. Recent findings suggest that PTTH stimulates ecdysone synthesis in the prothoracic glands via sugar metabolism. Given that ecdysone levels fail to rise when trehalose metabolism—an essential blood sugar in insects—is disrupted, these findings are particularly intriguing. This opinion paper discusses how PTTH activates prothoracic glands through sugar metabolism and proposes a model for systemic, midgut-mediated positive feedback regulation of ecdysone synthesis, integrating interorgan communication to coordinate developmental transitions. |
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| 資料連結 | ![Full Text]() |
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| 計畫主持人 | 顧世紅 |
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| 計畫年度 | 2025 |
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| 計畫委託單位 | 國科會 |
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| 計畫名稱 | 昆蟲胰島素的新功能：前胸腺自體分泌因子的探索 |
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| 系統號 | NO000007365 |
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